Water → HCID 66862914, compound

Participants

Reaction Steps

To a solution of the compound obtained in Example 26 (50 mg) in methanol (5 mL) was added 6N-ammonia-methanol (1 mL) and the mixture was stirred at room temperature overnight. To the reaction mixture was added ethyl acetate and water and the mixture was stirred. The organic layer was separated and concentrated in vacuo. The resultant crude product was purified by column chromatography on silica gel (solvent: hexane/ethyl acetate=50/50 to 30/70) to obtain 4-carbamoylmethoxy-1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-[N-(1-pyrrolidinyl)carbamoyl]-1H-pyrazole (10.2 mg, yield: 11%) as a pale yellow solid.

Provenance & Evidence