Triphenylphosphine → HCID 66863232, compound

Participants

Reaction Steps

To a solution of 1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-ethoxycarbonyl-4-hydroxy-1H-pyrazole (200 mg, compound obtained in Reference Example 1 (4)) in tetrahydrofuran (4 mL) was added triphenylphosphine (208 mg) and 2-morpholino-ethanol (96 μL) and the mixture was stirred. Thereto was added dropwise diisopropyl azodicarboxylate (154 μL) at 0° C. under nitrogen-gas atmosphere and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated in vacuo and the crude product was purified by column chromatography on silica gel (solvent: hexane/ethyl acetate=67/33 to 30/70) to obtain ethyl 1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-ethoxycarbonyl-4-(2-morpholinoethoxy)-1H-pyrazole (463 mg, yield: 100%) as a colorless viscidity.

Provenance & Evidence