Ethyl 3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate → Lithium benzomorpholine-2-carboxylate

Participants

Reaction Conditions

Reaction Steps

A solution of lithium hydroxide monohydrate (1.43 g, 34.2 mmol) in water (50 mL) was added to a solution of ethyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylate (3.55 g, 17.1 mmol) in dioxane (50 mL), and the mixture was stirred at 25° C. for 21 h. The reaction mixture was concentrated to afford the title compound. MS m/z: 180 (M+1 of acid).

Provenance & Evidence