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Dichloromethane → Cyclopentyl-1-cyclopentyl-6-oxo-1,6-dihydropyridazine-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Iodocyclopentane | HCID 73784 | — |
| 反応物 | 6-Hydroxypyridazine-3-carboxylic Acid | HCID 305970 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Cyclopentyl-1-cyclopentyl-6-oxo-1,6-dihydropyridazine-3-carboxylate | HCID 66845103 | — |
反応手順
6-Oxo-1,6-dihydropyridazine-3-carboxylic acid (1 g, 7.14 mmol) was stirred with cyclopentyl iodide (2.05 ml, 17.8 mmol) and potassium carbonate (3 g, 21.4 mmol) in 15 ml DMF for 14 h at room temperature. 50 ml CH2Cl2 was added and the reaction mixture was filtered. The filtrate was concentrated and the title compound was purified by prep HPLC. Yield: 20 mg (0.072 mmol, 1%, MS m/z: 277(100%, M+1)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07872009B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-c6df35c495594acebc47d27daaec753d |
| 出典メモ | uspto-grants-2011_01 |