Methylcyclohexane → HCID 86612304, compound

Participants

Reaction Steps

50 mg (0.144 mmol) of 3-chloro-4-[2-[[(1,1-dimethylethoxy)carbonyl]-amino]-ethylthio]benzeneacetic acid methyl ester are dissolved in 322 μl of trifluoroacetic acid. Agitation is performed for 2 hours at ambient temperature. The trifluoroacetic acid is eliminated by coevaporation with methylcyclohexane. The evaporation residue is dissolved in ethyl acetate and neutralisation takes place by addition of a solution of sodium carbonate at 10%. The organic phase is dried on magnesium sulfate, filtration takes place and concentration under reduced pressure. The expected product is obtained in the form of an orange oil with a quantitative yield.

Provenance & Evidence