4-(Benzyloxy)benzene-1-sulfonyl chloride → HCID 86612305, compound

HRID 253165Notes

Reaction equation

HRID 253165 reaction equation
[C:1]1([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([S:15](Cl)(=[O:17])=[O:16])=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:19][O:20][C:21]([C@@H:23]1[CH2:31][C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[NH:24]1)=[O:22]>>[C:1]1([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([S:15]([N:24]3[C:25]4[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH2:31][C@H:23]3[C:21]([O:20][CH3:19])=[O:22])(=[O:17])=[O:16])=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 47383854-(Benzyloxy)benzene-1-sulfonyl chlorideHCID 7020378(S)-(+)-Methyl indoline-2-carboxylate

Product 1

HCID 86612305HCID 86612305, compoundYield 81%

Procedure

Working in a manner similar to preparation IL, starting with the 4-(phenylmethoxy)benzenesulfonyl chloride and 2,3-dihydro-(2S)-1H-indole-2-carboxylic acid methyl ester, the expected product is obtained in the form of a white powder with a yield of 81%.

Workup

  1. customWorking in a manner similar to preparation IL

Sources & evidence

ORD record
ord-c08bcec5cce54cf89d64121c5b6d0ff4
Source dataset
uspto-grants-2011_01
Patent number
US07872021B2

Reaction notes

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