8-((1R)-1-Phenyl-ethyl)-3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic Acid Tert-Butyl Ester → cis-3-Boc-3,8-diazabicyclo[4.2.0]octane

Participants

Reaction Conditions

Reaction Steps

To the minor isomer product of Example 3E (2.4 g, 7.5 mmol) in 30 mL CH3OH was added 0.58 g of 20% Pd(OH)2/C (wet). This mixture was shaken under 60 psi of H2 for 16.5 h at 50° C. The mixture was filtered, concentrated to proved the title compound, suitable for use without further purification. MS (DCl/NH3) m/z 213 (M+H)+.

Provenance & Evidence