Fumaric Acid → HCID 131720573, compound

HRID 2532Notes

Reaction equation

[CH3:1][S:2]([NH:5][C:6]1[CH:37]=[CH:36][C:9]([C:10]([N:12]([CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][CH:24]([C:27](=[O:35])[C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=3)[CH2:23][CH2:22]2)[C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)=[O:11])=[CH:8][CH:7]=1)(=[O:4])=[O:3].[C:38]([OH:45])(=[O:44])/[CH:39]=[CH:40]/[C:41]([OH:43])=[O:42]>>[C:38]([OH:45])(=[O:44])/[CH:39]=[CH:40]/[C:41]([OH:43])=[O:42].[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([C:10]([N:12]([CH2:19][CH2:20][N:21]2[CH2:22][CH2:23][CH:24]([C:27](=[O:35])[C:28]3[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=3)[CH2:25][CH2:26]2)[C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)=[O:11])=[CH:36][CH:37]=1)(=[O:4])=[O:3].[CH3:1][S:2]([NH:5][C:6]1[CH:37]=[CH:36][C:9]([C:10]([N:12]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][CH:24]([C:27](=[O:35])[C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=3)[CH2:23][CH2:22]2)=[O:11])=[CH:8][CH:7]=1)(=[O:3])=[O:4]

Participants

Reactant 2

HCID 444972Fumaric Acid

HCID 19689835HCID 19689835, compound

Product 1

HCID 131720573HCID 131720573, compoundYield 43.3%

Procedure

Using 4-methanesulfonylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-pyridyl)benzamide (216.8 mg, 0.41 mmol) and fumaric acid (24.3 mg, 0.21 mmol), the procedure of Inventive Example 271 was repeated to obtain 103.4 mg (43.3%) of the title compound in a light brown powder form.

Sources & evidence

ORD record: ord-77277727d2c54daf907c8832e8787aea
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05728835

Reaction notes

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