L-Phenylalanine, 1,1-dimethylethyl ester, hydrochloride (1:1) → (S)-tert-butyl 2-amino-3-(1H-indol-3-yl)propanoate hydrochloride

HRID 25323Notes

Reaction equation

HRID 25323 reaction equation
[CH3:1][C:2]([O:5][C:6]([C@@H:8]([NH2:15])[C:9]1C=CC=CC=1)=[O:7])([CH3:4])[CH3:3].[ClH:16].Cl.C(OC(=O)[C@H:24]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[NH2:25])(C)(C)C>>[NH2:15][C@H:8]([C:6]([O:5][C:2]([CH3:4])([CH3:3])[CH3:1])=[O:7])[CH2:9][C:26]1[C:27]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[NH:25][CH:24]=1.[ClH:16]

Participants

3

Reactant 2

HCID 11459563L-Phenylalanine, 1,1-dimethylethyl ester, hydrochloride (1:1)HCID 45073229(S)-tert-Butyl 2-amino-2-phenylacetate hydrochloride

Product 1

HCID 11514895(S)-tert-butyl 2-amino-3-(1H-indol-3-yl)propanoate hydrochloride

Procedure

H-PhG-OtBu HCl for phenylalanine tert butyl ester hydrochloride, the following compounds were prepared:

Sources & evidence

ORD record
ord-67df8bd49fad4decbb51a7f462295b49
Source dataset
uspto-grants-2005_02
Patent number
US06858630B2

Reaction notes

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