m-Chloroperbenzoic acid → HCID 86628945, compound

Participants

Reaction Steps

1.9 g of [5-(5-amino-3-trifluoromethyl-1,2,4-triazolyl)-4-fluoro-2-methylphenyl]2,2,2-trifluoroethyl sulfide was dissolved in 100 ml of chloroform, and 1.0 g of m-chloroperbenzoic acid was added at 0° C., followed by stirring at room temperature for 1 hour. The solvent was distilled off under reduced pressure, and the obtained residue was purified by column chromatography (eluent ethyl acetate:hexane:triethylamine=50:50:1) to obtain 1.8 g of [5-(5-amino-3-trifluoromethyl-1,2,4-triazolyl)-4-fluoro-2-methylphenyl]2,2,2-trifluoroethyl sulfoxide as pale yellow crystals (melting point 236 to 238° C.).

Provenance & Evidence