m-Chloroperbenzoic acid → HCID 86628948, compound

Participants

Reaction Steps

0.8 g of [5-(5-trifluoroacetylamino-3-trifluoromethyl-1,2,4-triazolyl)-4-fluoro-2-methylphenyl]2,2,2-trifluoroethyl sulfide was dissolved in 50 ml of chloroform, and 0.3 g of m-chloroperbenzoic acid was added at 0° C., followed by stirring at room temperature for 1 hour. The solvent was distilled off under reduced pressure, and the obtained solid was purified by column chromatography (eluent ethyl acetate:hexane=1:1) to obtain 0.6 g of [5-(5-trifluoroacetylamino-3-trifluoromethyl-1,2,4-triazolyl)-4-fluoro-2-methylphenyl]2,2,2-trifluoroethyl sulfoxide as a pale yellow powder (melting point 233 to 237° C.).

Provenance & Evidence