Cuminaldehyde → 4-Iodomethyl-2-(4-isopropylphenyl)-5-methyloxazole

HRID 253355Notes

Reaction equation

HRID 253355 reaction equation
[I:1][CH2:2][C:3]1[N:4]=C(C2C=CC(C)=CC=2)O[C:7]=1[C:8]1C=CC=CC=1.C/C(/C(C)=O)=N\O.[CH:28]([C:31]1[CH:38]=[CH:37][C:34]([CH:35]=[O:36])=[CH:33][CH:32]=1)([CH3:30])[CH3:29]>>[I:1][CH2:2][C:3]1[N:4]=[C:35]([C:34]2[CH:33]=[CH:32][C:31]([CH:28]([CH3:30])[CH3:29])=[CH:38][CH:37]=2)[O:36][C:7]=1[CH3:8]

Participants

4

Reactant 3

HCID 326CuminaldehydeHCID 64096332,3-Butanedione monoximeHCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 574345184-Iodomethyl-2-(4-isopropylphenyl)-5-methyloxazole

Procedure

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, diacetylmonoxime and 4-isopropylbenzaldehyde gave 4-iodomethyl-2-(4 isopropylphenyl)-5-methyloxazole.

Sources & evidence

ORD record
ord-54844e62f87e4d49957420995c2d57ff
Source dataset
uspto-grants-2011_01
Patent number
US07872034B2

Reaction notes

Loading…