1H-Pyrrolo(2,3-b)pyridine → HCID 58087841, compound

HRID 253377Notes

Reaction equation

HRID 253377 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][O:7][C:8]2[CH:15]=[CH:14][C:11]([CH:12]=O)=[CH:10][C:9]=2[O:16][CH3:17])=[CH:4][CH:3]=1.[NH:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][N:27]=2)[CH:22]=[CH:21]1>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][O:7][C:8]2[CH:15]=[CH:14][C:11]([CH2:12][C:22]3[C:23]4[C:28](=[N:27][CH:26]=[CH:25][CH:24]=4)[NH:20][CH:21]=3)=[CH:10][C:9]=2[O:16][CH3:17])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 92221H-Pyrrolo(2,3-b)pyridineHCID 7182634-[(4-Chlorophenyl)methoxy]-3-methoxybenzaldehyde

Product 1

HCID 58087841HCID 58087841, compound

Procedure

Additional compounds were prepared using the protocol of Scheme 7, Steps 2 and 3, replacing 4-(4-chlorobenzyloxy)-3-methoxybenzaldehyde 23 with a suitable aldehyde (prepared as described in Example 15 or 33), and optionally replacing 1H-Pyrrolo[2,3-b]pyridine 6 with an appropriate substituted 7-azaindole (5-chloro-7-azaindole per Example 4 or 5-methoxy-7-azaindole per Example 8) in Step 2. The following compounds were made following this procedure:

Workup

  1. customAdditional compounds were prepared

Sources & evidence

ORD record
ord-b219604b662f4cbbacb3bf48e76cf16f
Source dataset
uspto-grants-2011_01
Patent number
US07872018B2

Reaction notes

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