1H-Pyrrolo(2,3-b)pyridine → HCID 58086181, compound

Participants

Reaction Steps

was prepared following the protocol of Scheme 8, substituting 5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridine 20 with 7-azaindole 6 in Step 3. To a solution of (3-benzyloxy-2,6-difluoro-phenyl)-(1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone (P-1802, 0.5 g, 1.37 mol) in methanol (70 mL) and tetrahydrofuran (30 mL) was added palladium on carbon (120 mg, 10% wt., 0.58 mol). The mixture was stirred under hydrogenation (60 psi) for six hours. After removal of solvent, the residue was dried under vacuum, which provided (2,6-Difluoro-3-hydroxy-phenyl)-(1H-pyrrolo[2,3-b]pyridine-3-yl)-methanone 89

Provenance & Evidence