HCID 58086605, compound → HCID 58086937, compound

HRID 253421Notes

Reaction equation

[CH2:1]([O:8][C:9]1[C:10]([F:33])=[C:11]([C:16]([C:18]2[C:26]3[C:21](=[N:22][CH:23]=[C:24](C4C=NC=CC=4)[CH:25]=3)[NH:20][CH:19]=2)=[O:17])[C:12]([F:15])=[CH:13][CH:14]=1)C1C=CC=CC=1.FC1C(O)=CC=C(F)C=1C(C1[C:53]2[C:48](=[N:49][CH:50]=[C:51](Cl)[CH:52]=2)NC=1)=O>>[F:33][C:10]1[C:9]([O:8][CH2:1][C:53]2[CH:48]=[N:49][CH:50]=[CH:51][CH:52]=2)=[CH:14][CH:13]=[C:12]([F:15])[C:11]=1[C:16]([C:18]1[C:26]2[C:21](=[N:22][CH:23]=[CH:24][CH:25]=2)[NH:20][CH:19]=1)=[O:17]

Participants

Reactant 2

HCID 58086605HCID 58086605, compound

HCID 66889313HCID 66889313, compound

Product 1

HCID 58086937HCID 58086937, compound

Procedure

Additional compounds were prepared following the protocol of Scheme 28, replacing pyridin-3-yl-methanol 90 with an appropriate alcohol and optionally replacing (2,6-difluoro-3-hydroxy-phenyl)-(1H-pyrrolo[2,3-b]pyridine-3-yl)-methanone 89 with (2,6-difluoro-3-hydroxy-phenyl)-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-yl)-methanone (prepared as described in Example 11, 3 and 4 of Scheme 8, replacing pyridin-3-yl-1H-pyrrolo[2,3-b]pyridine 20 with 5-chloro-1H-pyrrolo[2,3-b]pyridine 4 (see Example 4) in Step 3). The following compounds were made following this procedure:

Workup

customAdditional compounds were prepared

Sources & evidence

ORD record: ord-c7e4c7ce05684042a22ea5120087acd4
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07872018B2

Reaction notes

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