5-Chloro-1H-pyrrolo[2,3-b]pyridine → [2-chloro-6-fluoro-3-(2-methoxy-ethoxy)-phenyl]-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone

Participants

Reaction Steps

Additional compounds were prepared using the protocol of Scheme 41, optionally substituting 2-chloro-6-fluoro-3-(2-methoxy-ethoxy)-benzaldehyde 123 with a suitable aldehyde (prepared as described in Examples 36, 39 or 40), and/or optionally replacing 5-chloro-1H-pyrrolo[2,3-b]pyridine 4 with an appropriate substituted 7-azaindole (5-methoxy-7-azaindole per Example 8, 5-(1-methyl-1H-pyrazol-4-yl)-7-azaindole per Example 35) in Step 1. The following compounds were made following this procedure:

Provenance & Evidence