Sodium Hydroxide → 4'-(3-Butylaminopropoxy)-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylic acid

Participants

Reaction Steps

In a manner similar to that of Example 2a, by reaction of 410 mg (10 mmol) of sodium hydroxide with 360 mg (0.7 mmol) of ethyl 4′-(3-butylaminopropoxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate (Example 5a) in 30 ml of tetrahydrofuran. 70 mg of 4′-(3-butylaminopropoxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylic acid are obtained in the form of a white solid (m.p.=238° C., yield=20%).

Provenance & Evidence