Dimethylamine → 5-Amino-1-(2-chloro-6-dimethylamino-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylsulfonylpyrazole

Participants

Reaction Conditions

Reaction Steps

To a mixture of 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylsulfonylpyrazole (0.5 g, 1.1 mmol) in dioxan (5 ml) was added dimethylamine (aqueous solution 60%, 0.33 g, 4.4 mmol). The mixture was heated at 200° C. for 30 min in the microwave oven (Smith Synthesizer) under pressure. After extractive workup (heptane-ethyl acetate, water) and column chromatography the title product was obtained (0.18 g), mp 197° C., 1H-NMR: 2.75 (6H), 6.27 (2H), 7.13 and 7.24 (2H); 19F-NMR: −64.0, −80.6.

Provenance & Evidence