Water → HCID 11270433, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 5-amino-1-(2-chloro-6-methoxy-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole (Compound number 8-04, 1.04 g, 2.4 mmol) in dichloroethane (10 ml) was added peroxyacetic acid (acetic acid solution 35%, 0.62 g, 2.9 mmol). The mixture was stirred at 20° C. for 20 hours. After extractive workup (heptane-ethyl acetate, water) and column chromatography the title product was obtained (0.55 g). Two diastereomers were observed in NMR and HPLC (46% and 49%), mp 195° C., 1H-NMR: 3.94 (3H), 5.04 (2H), 7.24 and 7.49; 19F-NMR: −63.9, −75.3 and −75.4.

Provenance & Evidence