2-Chloroethyl methyl sulfide → HCID 86619000, compound

Participants

Reaction Steps

To a mixture of 1-(2-chloro-6-dimethylamino-4-trifluoromethylphenyl)-3-cyano-5-methylamino-4-trifluoromethylthiopyrazole (Compound number 4-01, 0.29 g, 0.7 mmol) in acetonitrile (6 ml) was added chloroethyl methylsulfide (87 mg, 0.8 mmol) and potassium phosphate (0.42 g, 2.0 mmol). The mixture was heated under reflux for 4 hours. After extractive workup (heptane-ethyl acetate, water) and reverse HPLC chromatography the title product was obtained (0.16 g), 1H-NMR: 1.99 (3H), 2.31 (2H), 2.69 (6H), 2.85 (3H), 3.18 (2H), 7.15 and 7.29; 19F-NMR: −44.7, −63.9.

Provenance & Evidence