Ammonium Hydroxide → tert-butyl (2S,3S)-4-amino-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate

Participants

Reaction Steps

To a stirred solution of tert-butyl (S)-2-cyclohexyl-1-((R)-oxiran-2-yl)ethylcarbamate (0.20 g, 0.74 mmol) in MeOH (15 mL) at rt, ammonium hydroxide (5 mL) was added. The resulting clear solution was stirred at rt overnight, and completion of reaction was confirmed by LC-MS. Solvent was removed under vacuum to leave tert-butyl (2S,3S)-4-amino-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate (0.21 g, quant.), which was used for the next step without purification; M/S m/z 287 (M+H+).

Provenance & Evidence