Hydrochloric Acid → (2R,3S)-3-Amino-1-azido-4-cyclohexylbutan-2-ol

Participants

Reaction Steps

(2R,3S)-3-(t-Butoxycarbonylamino)-1-azido-4-cyclohexylbutan-2-ol (94 mg, (0.30 mmol) was dissolved in dioxane (1 mL) and treated with 4M HCl in dioxane (1 mL). The reaction was allowed to stir for 2 h at rt. The solvent was evaporated and the hydrochloric acid salt of (3R)-3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)-N-(piperidin-3-yl)piperidine-1-carboxamide (˜74 mg) was used directly.

Provenance & Evidence