HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 253584Generated: October 26, 2026
Methylamine ethanol → tert-butyl (2S,3R)-3-hydroxy-4-(methylamino)-1-(tetrahydro-2H-pyran-4-yl)butan-2-ylcarbamate
https://huagongshe.com/reaction/253584
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine ethanol | HCID 22028356 | — |
| Reactant | [1-Oxiranyl-2-(tetrahydro-pyran-4-yl)-ethyl]-carbamic acid tert-butyl ester | HCID 76605248 | — |
| Product | tert-butyl (2S,3R)-3-hydroxy-4-(methylamino)-1-(tetrahydro-2H-pyran-4-yl)butan-2-ylcarbamate | HCID 57786531 | — |
Reaction Steps
A 250 mL flask was charged with [1-oxiranyl-2-(tetrahydro-pyran-4-yl)-ethyl]-carbamic acid tert-butyl ester (150 mg, 0.55 mmol) dissolved in MeNH2/EtOH solution and stirred overnight at 30-40° C. Then the mixture was concentrated and used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07872028B2 |
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| Source dataset | uspto-grants-2011_01 |
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| ORD ID | ord-309c611308dd444d9a815a6ce47bffbb |
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| Source note | uspto-grants-2011_01 |
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