Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

A solution of tert-butyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-(2-(3-((3-methoxypropoxy)-(phenyl)methyl)piperidin-1-yl)-3,4-dioxocyclobut-1-enylamino)butylcarbamate (37 mg, 0.06 mmol) was dissolved in dioxane (1 mL) and treated with 4M HCl in dioxane (1 mL). The reaction was allowed to stir for 3 h. Evaporation of the solvent provided 3-((2S,3R)-4-amino-1-cyclohexyl-3-hydroxybutan-2-ylamino)-4-(3-((3-methoxypropoxy)(phenyl)methyl)piperidin-1-yl)cyclobut-3-ene-1,2-dione as its HCl salt (32 mg); MS m/z 528 (M+H+).

Provenance & Evidence