Sulfamic Acid → HCID 901406, compound

HRID 253632Notes

Reaction equation

HRID 253632 reaction equation
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([O:12][CH3:13])=[C:8]([CH:11]=1)[CH:9]=[O:10])([CH3:3])[CH3:2].S(=O)(=O)([OH:16])N.Cl([O-])=O.[Na+]>CC(C)=O.O>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([O:12][CH3:13])=[C:8]([CH:11]=1)[C:9]([OH:16])=[O:10])([CH3:3])[CH3:2]

Participants

6

Reactant 3

HCID 5987Sulfamic AcidHCID 70095025-ISOPROPYL-2-METHOXYBENZALDEHYDEHCID 23668197Sodium Chlorite

Product 1

HCID 901406HCID 901406, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

5-Isopropyl-2-methoxybenzaldehyde (2.8 g, 15.7 mmol) was dissolved in acetone (40 mL). To this solution was added sulfamic acid (2.29 g, 23.57 mmol) and sodium chlorite (1.71 g, 18.85 mmol) in water (40 mL). The mixture was stirred at rt in an open flask for 12 hrs. The acetone was removed and the mixture was extracted with Et2O. The organic layer was dried over MgSO4, filtered and concentrated to afford the title compound. MS (DCI/NH4+) m/z 212 (M+NH4)+.

Workup

  1. customThe acetone was removed
  2. extractionthe mixture was extracted with Et2O
  3. dry with materialThe organic layer was dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-b32c033ac80a4904a80bab2636172deb
Source dataset
uspto-grants-2011_01
Patent number
US07872033B2

Reaction notes

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