1-(2-Chloro-4-fluorophenyl)cyclohexanecarboxylic acid → HCID 178441258, compound

Participants

Role	Name	HCID	Charge
Reactant	1-(2-Chloro-4-fluorophenyl)cyclohexanecarboxylic acid	HCID 1268166	—
Reactant	2-tert-Butyl-4-butylisothiazol-5(2H)-imine	HCID 66867228	—
Product	HCID 178441258	HCID 178441258	—

Reaction Steps

The product from Example 92B and (2-chloro-4-fluorophenyl)cyclohexanecarboxylic acid (Acros) were processed using the method described in Example 92C to afford the title compound. 1H NMR (DMSO-d6) δ 0.76 (t, J=7.3 Hz, 3H), 1.06-1.18 (m, 2H), 1.33-1.53 (m, 8H), 1.56 (s, 9H), 1.71-1.81 (m, 2H), 1.92-2.00 (m, 2H), 2.34-2.42 (m, 2H), 7.14-7.22 (m, 2H), 7.57 (dd, J=8.6, 6.3 Hz, 1H), 8.46 (s, 1H). MS (ESI+) m/z 451 (M+H)+. Anal. calcd. for C24H32ClFN2OS: C, 63.91; H, 7.15; N, 6.21. Found: C, 64.04; H, 7.08; N, 6.10.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07872033B2
Source dataset	uspto-grants-2011_01
ORD ID	ord-18875a6035b54c1795abf0e33acb9b47
Source note	uspto-grants-2011_01