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HRID25368

反应详情

EQUATION

反应方程式

HRID 25368 的结构方程式

REACTANTS

反应物

3
结构：C1CCOC1
HCID8028

Tetrahydrofuran

C4H8O

结构：CS(=O)(=O)c1ccccc1S(=O)(=O)Cl
HCID2735178

2-(methylsulfonyl)benzenesulfonyl chloride

C7H7ClO4S2

结构：Cc1nn(C(=O)OC(C)(C)C)c2ccc(N)cc12
HCID59276571

未命名化合物

PRODUCTS

生成物

1
结构：Cc1nn(C(=O)OC(C)(C)C)c2ccc(NS(=O)(=O)c3ccccc3S(C)(=O)=O)cc12
HCID22567145

1,1-Dimethylethyl 3-methyl-5-[[[2-(methylsulfonyl)phenyl]sulfonyl]amino]-1H-indazole-1-carboxylate

C20H23N3O6S2

收率 88.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

N-(N-tert-Butoxycarbonyl-3-methyl-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide can be obtained as described in Example 1 from 0.9 g of 5-amino-N-tert-butoxycarbonyl-3-methyl-1H-indazole, 55 ml of tetrahydrofuran, 1 ml of triethylamine and 1.02 g of 2-methylsulfonylbenzenesulfonyl chloride. 1.5 g of N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide are thus obtained in the form of a pink solid melting at 228° C.