反应详情

温度

90 °C

To 2-amino-5-nitropyrimidine (0.42 g, 3.0 mmol) dissolved in toluene (2 ml) was added acetic anhydride (1.4 ml, 15 mmol). The reaction mixture was stirred at 90° C. for 15 hr, after which an additional amount of acetic anhydride was added (0.7 mL) and the mixture was stirred at reflux for another 16 h. The solvent was removed in vacuo and to the residue was added hexane (10 mL) and DCM (1 mL). The solid was collected by filtration, dried to give N-(5-nitropyrimidin-2-yl)acetamide as an off-white solid. MS (ESI, pos. ion) m/z: 183 (M+1).

1. stirringthe mixture was stirred
2. temperatureat reflux for another 16 h
3. customThe solvent was removed in vacuo and to the residue
4. additionwas added hexane (10 mL) and DCM (1 mL)
5. filtrationThe solid was collected by filtration
6. customdried