HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluoroaniline → 1-(4-Amino-3-fluorophenyl)pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluoroaniline | HCID 123050 | — |
| Reactant | HCID 178516071 | HCID 178516071 | — |
| Catalyst | Copper | HCID 23978 | — |
| Product | 1-(4-Amino-3-fluorophenyl)pyridin-2-one | HCID 22181548 | — |
Reaction Steps
The process described in patent US2005/0215599, i.e. copper catalyzed N-arylation of 2-hydroxypyridine with 4-bromo-2-fluoroaniline suffers from a major safety issue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07872141B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-40ea8693295642358fca22f78da3d1b5 |
| Source note | uspto-grants-2011_01 |