化工社化工社 化学情報印刷レポート · 研究参考用
3-(Trifluoromethyl)phenyl isocyanate → N-[3-(trifluoromethyl)phenyl]-1,3,4,9-tetrahydro-2H-beta-carboline-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Trifluoromethyl)phenyl isocyanate | HCID 9483 | — |
| 反応物 | Tetrahydro-beta-carboline | HCID 107838 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-[3-(trifluoromethyl)phenyl]-1,3,4,9-tetrahydro-2H-beta-carboline-2-carboxamide | HCID 23113599 | 61.7% |
反応手順
A solution of 2,3,4,9-tetrahydro-1H-β-carboline (172 mg) in dimethylformamide (5 mL) was added by a solution of 1-isocyanato-3-(trifluoromethyl)benzene (173 mg) in dichloromethane (5 mL) and stirred overnight at the room temperature. The mixture was concentrated under reduced pressure and the residue was purified by column chromatography on silica gel (hexane:ethyl acetate=6:1) to give the title compound (205 mg) having the following physical data.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07872133B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-9ebe548c246e451ab7c77a5d5b14032b |
| 出典メモ | uspto-grants-2011_01 |