Hydrochloric Acid → HCID 23154708, compound

Participants

Reaction Conditions

Reaction Steps

In a 25 ml flask was prepared a solution of 2-methyl-4-(2-nitro-phenyl)-pentan-3-one (390 mg, 1.8 mmol) in dry methanol (9 ml). It is cooled with an ice-water bath. The temperature in the reaction mixture was 4° C. Sodium borohydride (73 mg, 1.9 mmol) was added, spoon by spoon. It was stirred one hour at 0° C. The cooled mixture was added to HCl 1N (7 ml). This addition was exothermic. Methanol was evaporated. The aqueous phase was extracted with ethyl acetate (50 ml). The organic phase was washed with water (1×25 ml), brine (1×25 ml) and dried with magnesium sulfate. 2-methyl-4-(2-nitro-phenyl)-pentan-3-ol (380 mg—yield 97%) was then obtained as a pale yellow oil.

Provenance & Evidence