HCID 23154708, compound → HCID 23154705, compound

HRID 253734Notes

Reaction equation

HRID 253734 reaction equation
[CH3:1][CH:2]([CH:4]([OH:16])[CH:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N+:13]([O-])=O)[CH3:6])[CH3:3]>CCO.[Pd]>[CH3:3][CH:2]([CH:4]([OH:16])[CH:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[NH2:13])[CH3:6])[CH3:1]

Participants

4

Reactant 1

HCID 23154708HCID 23154708, compound

Product 1

HCID 23154705HCID 23154705, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

In a 15 ml hydrogenation reactor was charged a solution of 2-methyl-4-(2-nitro-phenyl)-pentan-3-ol (370 mg, 1.7 mmol) in EtOH (12 ml). Pd/C5% was added. The reaction mixture was stirred under hydrogen (4 bars) at room temperature for 2 hours. Filtration through celite and evaporation of ethanol afforded 2-methyl-4-(2-amino-phenyl)-pentan-3-ol as a white solid (320 mg-quantitative yield).

Workup

  1. filtrationFiltration
  2. customthrough celite and evaporation of ethanol

Sources & evidence

ORD record
ord-fa7bda2535a7462a8a6beee9ea09eed2
Source dataset
uspto-grants-2011_01
Patent number
US07872146B2

Reaction notes

Loading…