HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluorobenzoyl chloride → N-(2,6-difluorobenzoyl)-L-tyrosine tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluorobenzoyl chloride | HCID 87438 | — |
| Reactant | L-Tyrosine 1,1-dimethylethyl ester | HCID 6950582 | — |
| Product | N-(2,6-difluorobenzoyl)-L-tyrosine tert-butyl ester | HCID 66843056 | — |
Reaction Steps
L-tyrosine tert-butyl ester (10.0 g) was acylated with 2,6-difluorobenzoyl chloride in a similar manner as described Example 1-(5) to give N-(2,6-difluorobenzoyl)-L-tyrosine tert-butyl ester (15.9 g). mp. 145-148° C.; IR (Nujol) 1728, 1638 cm−1; MS (APCI) m/z 395 (M+NH4), 378 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07872151B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-ed4f534cb0124596a6078e226af97ec8 |
| Source note | uspto-grants-2011_01 |