2-Chloro-N,N-dimethylethylamine → 1,1-Dicyclohexyl-3-[5-(2-dimethylamino-ethylsulfanyl)-4-methyl-thiazol-2-yl]-urea
Reaction equation
[CH:1]1([N:7]([CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[C:8]([NH:10][C:11]2[S:12][C:13]([S:17][C:18]#N)=[C:14]([CH3:16])[N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:26][N:27]([CH2:29]CCl)[CH3:28]>>[CH:1]1([N:7]([CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[C:8]([NH:10][C:11]2[S:12][C:13]([S:17][CH2:18][CH2:26][N:27]([CH3:29])[CH3:28])=[C:14]([CH3:16])[N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1Participants
3
Procedure
Prepared as described in general procedure (H) using 1,1-dicyclohexyl-3-(4-methyl-5-thiocyanato-thiazol-2-yl)-urea and dimethylaminoethylchloride.
Workup
- customPrepared
Sources & evidence
- ORD record
- ord-9900fd1449bb4e42be4a7e0ee629494a
- Source dataset
- uspto-grants-2011_01
- Patent number
- US07872139B2
Reaction notes
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