HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → N-phenyl-5-(3-fluorobenzenesulfonylamino)-1H-indazole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 22567186 | HCID 22567186 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-phenyl-5-(3-fluorobenzenesulfonylamino)-1H-indazole-3-carboxamide | HCID 10454214 | 12.7% |
Reaction Steps
N-Phenyl-5-(3-fluorobenzenesulfonylamino)-1H-indazole-3-carboxamide can be obtained as described in Example 18 from 0.45 g of 5-(3-fluorobenzenesulfonylamino)-1H-indazole-3-carboxylic acid, 11 ml of dimethylformamide, 0.56 g of 0-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate, 0.38 g of diisopropylethylamine and 0.14 g of aniline. 70 mg of N-phenyl-5-(3-fluorobenzenesulfonylamino)-1H-indazole-3-carboxamide are thus obtained in the form of a brown solid melting above 260° C. (Analysis: C20H15FN4O3S.0.73H2O % calculated C, 58.54; H, 3.68; F, 4.63; N, 13.65; O, 11.69; S, 7.81. % found C, 58.09; H, 3.18; N, 13.58; S, 7.43).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06858638B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-1510b2f7e2154c1f8fdc48271f6f7b52 |
| Source note | uspto-grants-2005_02 |