N,N-dimethylpiperazine-1-sulfonamide hydrochloride → HCID 178486176, compound

HRID 253828Notes

Reaction equation

HRID 253828 reaction equation
[CH:1]1([N:7]([C@H:18]2[CH2:23][CH2:22][C@H:21]([CH3:24])[CH2:20][CH2:19]2)[C:8]([NH:10][C:11]2[S:12][C:13]([CH:16]=O)=[CH:14][N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[CH3:26][N:27]([CH3:37])[S:28]([N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1)(=[O:30])=[O:29]>>[CH3:26][N:27]([CH3:37])[S:28]([N:31]1[CH2:36][CH2:35][N:34]([CH2:16][C:13]2[S:12][C:11]([NH:10][C:8]([N:7]([CH:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)[C@H:18]3[CH2:19][CH2:20][C@H:21]([CH3:24])[CH2:22][CH2:23]3)=[O:9])=[N:15][CH:14]=2)[CH2:33][CH2:32]1)(=[O:29])=[O:30]

Participants

3

Reactant 2

HCID 22031678N,N-dimethylpiperazine-1-sulfonamide hydrochlorideHCID 178461373HCID 178461373, compound

Product 1

HCID 178486176HCID 178486176, compound

Procedure

Prepared in 62% (326 mg) yield as described in general procedure (B) from trans-1-cyclohexyl-3-(5-formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-urea (349 mg, 1.0 mmol) and piperazine-1-sulfonic acid dimethylamide hydrochloride (230 mg, 1 mmol).

Workup

  1. customPrepared in 62% (326 mg)
  2. customyield

Sources & evidence

ORD record
ord-60a7d2c3fedd40e786ebcb2bafe2407c
Source dataset
uspto-grants-2011_01
Patent number
US07872139B2

Reaction notes

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