HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Piperazin-1-yl)propan-1-one → 1,1-Dicyclohexyl-3-[5-(4-propionyl-piperazin-1-ylmethyl)-thiazol-2-yl]-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Piperazin-1-yl)propan-1-one | HCID 3844375 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 1,1-Dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea | HCID 57883471 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1,1-Dicyclohexyl-3-[5-(4-propionyl-piperazin-1-ylmethyl)-thiazol-2-yl]-urea | HCID 57883729 | 15% |
Reaction Steps
Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (60 mg, 0.18 mmol), 1-piperazinyl-1-propanone (39 mg, 0.22 mmol), catalytic acetic acid and sodium triacetoxyborohydride (47 mg, 0.22 mmol) to afford 12 mg (15%) of the desired product after purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07872139B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-60825e8aca8f4cc3844cc522b2802726 |
| Source note | uspto-grants-2011_01 |