HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 253864Generated: October 25, 2026
1,1'-Carbonyldiimidazole → 4-[3-(5-Formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester
https://huagongshe.com/reaction/253864
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 2-Amino-1,3-thiazole-5-carbaldehyde | HCID 2737798 | — |
| Reactant | 4-(4-Methyl-cyclohexylamino)-piperidine-1-carboxylic acid tert-butyl ester | HCID 43652146 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[3-(5-Formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester | HCID 57883803 | 357.1% |
Reaction Steps
Prepared in a manner similar to general procedure (C) using 5-formyl-2-aminothiazole (1.88 g, 14.6 mmol), 4-(4-methyl-cyclohexylamino)-piperidine-1-carboxylic acid tert-butyl ester (4.32 mg, 14.6 mmol), catalytic DMAP, CDI (2.60 g, 1.1 mmol) and THF with heating to 65° C. afforded 1.77 g (27%) of the desired product after purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07872139B2 |
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| Source dataset | uspto-grants-2011_01 |
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| ORD ID | ord-22c53b1fc3d849d1a6e3060e342c94e5 |
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| Source note | uspto-grants-2011_01 |
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