Morpholine → 1,1-Dicyclohexyl-3-[4-(morpholine-4-carbonyl)thiazol-2-yl]-urea

HRID 253876Notes

Reaction equation

HRID 253876 reaction equation
[CH:1]1([N:7]([CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[C:8](=[O:18])[NH:9][C:10]2[S:11][CH:12]=[C:13]([C:15](O)=[O:16])[N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1>>[CH:1]1([N:7]([CH:19]2[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]2)[C:8]([NH:9][C:10]2[S:11][CH:12]=[C:13]([C:15]([N:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[O:16])[N:14]=2)=[O:18])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 578836042-(3,3-Dicyclohexylureido)-thiazole-4-carboxylic acid

Product 1

HCID 578837851,1-Dicyclohexyl-3-[4-(morpholine-4-carbonyl)thiazol-2-yl]-ureaYield 24%

Procedure

Prepared in 24% yield (61 mg) as described in general procedure (K) from 2-(3,3-dicyclohexylureido)-thiazole-4-carboxylic acid (210 mg, 0.60 mmol) and morpholine (52 mg, 0.60 mmol).

Workup

  1. customPrepared in 24% yield (61 mg)

Sources & evidence

ORD record
ord-fc9b5358c392426a8fbcafa8c9e6f3cd
Source dataset
uspto-grants-2011_01
Patent number
US07872139B2

Reaction notes

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