2-(chloromethyl)-4,5-dihydro-1H-imidazole → 1,1-Dicyclohexyl-3-[5-(4,5-dihydro-1H-imidazol-2-ylmethylsulfanyl)-thiazol-2-yl]-urea

HRID 253891Notes

Reaction equation

HRID 253891 reaction equation
[CH:1]1([N:7]([CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[C:8]([NH:10][C:11]2[S:12][C:13]([S:16]C#N)=[CH:14][N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.SC[C@@H]([C@@H](CS)O)O.Cl[CH2:34][C:35]1[NH:36][CH2:37][CH2:38][N:39]=1>>[CH:19]1([N:7]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[C:8]([NH:10][C:11]2[S:12][C:13]([S:16][CH2:34][C:35]3[NH:39][CH2:38][CH2:37][N:36]=3)=[CH:14][N:15]=2)=[O:9])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

4

Reactant 3

HCID 4263282-(chloromethyl)-4,5-dihydro-1H-imidazoleHCID 439352DithioerythritolHCID 866111921,1-Dicyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea

Product 1

HCID 578838441,1-Dicyclohexyl-3-[5-(4,5-dihydro-1H-imidazol-2-ylmethylsulfanyl)-thiazol-2-yl]-urea

Procedure

Prepared as described in general procedure (H) using 1,1-dicyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and 2-chloromethyl-2-imidazoline.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-369a8a4a72c9454ca62c542c80651cec
Source dataset
uspto-grants-2011_01
Patent number
US07872139B2

Reaction notes

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