Dithioerythritol → 3-[5-(2-Azepan-1-yl-ethylsulfanyl)-thiazol-2-yl]-1,1-dicyclohexyl-urea

HRID 253892Notes

Reaction equation

HRID 253892 reaction equation
[CH:1]1([N:7]([CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[C:8]([NH:10][C:11]2[S:12][C:13]([S:16]C#N)=[CH:14][N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.SC[C@@H]([C@@H](CS)O)O.[N:33](=[CH:41][CH2:42]Cl)[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]Cl>>[N:33]1([CH2:41][CH2:42][S:16][C:13]2[S:12][C:11]([NH:10][C:8](=[O:9])[N:7]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[CH:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)=[N:15][CH:14]=2)[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1

Participants

4

Reactant 3

HCID 439352DithioerythritolHCID 534452782-(Hexamethyleneimino)ethyl chlorideHCID 866111921,1-Dicyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea

Product 1

HCID 578838553-[5-(2-Azepan-1-yl-ethylsulfanyl)-thiazol-2-yl]-1,1-dicyclohexyl-urea

Procedure

Prepared as described in general procedure (H) using 1,1-dicyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and 2-(hexamethyleneimino)ethylchloride

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5a072e57e2584107a11cacf566acb00c
Source dataset
uspto-grants-2011_01
Patent number
US07872139B2

Reaction notes

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