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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 253899Generated: October 27, 2026

1-(2-Chloroethyl)pyrrolidine → 1-(1-Acetyl-piperidin-4-yl)-1-cyclohexyl-3-[5-(2-pyrrolidin-1-yl-ethylsulfanyl)-thiazol-2-yl]-urea

https://huagongshe.com/reaction/253899

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Chloroethyl)pyrrolidineHCID 81669—
ReactantDithioerythritolHCID 439352—
Reactant1-(1-Acetyl-piperidin-4-yl)-1-cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-ureaHCID 86611190—
Product1-(1-Acetyl-piperidin-4-yl)-1-cyclohexyl-3-[5-(2-pyrrolidin-1-yl-ethylsulfanyl)-thiazol-2-yl]-ureaHCID 57883587—

Reaction Steps

Prepared as described in general procedures (H) and (I) using 1-(1-acetyl-piperidin-4-yl)-1-cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and N-(2-chloroethyl)pyrrolidine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07872139B2
Source datasetuspto-grants-2011_01
ORD IDord-5b56804c0f0640c386af1365139dbf31
Source noteuspto-grants-2011_01