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HRID25390

反应详情

EQUATION

反应方程式

HRID 25390 的结构方程式

REACTANTS

反应物

2
结构：O=S(=O)(Cl)c1cccc(F)c1
HCID2734258

3-Fluorobenzenesulfonyl chloride

C6H4ClFO2S

结构：CS(=O)(=O)Nc1n[nH]c2ccc(N)cc12
HCID22567284

未命名化合物

PRODUCTS

生成物

1
结构：CS(=O)(=O)Nc1n[nH]c2ccc(NS(=O)(=O)c3cccc(F)c3)cc12
HCID22567191

未命名化合物

收率 18.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

3-Fluoro-N-(3-methylsulfonylamino-1H-indazol-5-yl)benzenesulfonamide can be obtained as described in Example 2 from 0.1 g of 5-amino-3-methylsulfonylamino-1H-indazole, 5 ml of pyridine and 83 mg of 3-fluorobenzenesulfonyl chloride. 30 mg of 3-fluoro-N-(3-methylsulfonylamino-1H-indazol-5-yl)benzenesulfonamide are thus obtained in the form of a beige solid melting at 230° C. (analysis C14H13FN4O4S2.0.57H2O % calculated C, 43.75; H, 3.41; F, 4.94; N, 14.57; O, 16.65; S, 16.68. % found C, 43.75; H, 2.86; N, 14.77; S, 15.93).