HCID 66872161, compound → HCID 57883716, compound

HRID 253906Notes

Reaction equation

HRID 253906 reaction equation
C([O:3][C:4](=[O:30])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[CH:16]2[CH2:21][CH2:20][C:19]([F:23])([F:22])[CH2:18][CH2:17]2)=[O:14])=[N:9][CH:8]=1)C.C1(NC2CCC(F)(F)CC2)CCCCC1.NC1SC=NC=1.C(OC(=O)CS)C>>[CH:24]1([N:15]([CH:16]2[CH2:17][CH2:18][C:19]([F:22])([F:23])[CH2:20][CH2:21]2)[C:13](=[O:14])[NH:12][C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:30])=[O:3])=[CH:8][N:9]=2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

4

Reactant 3

HCID 66872161HCID 66872161, compoundHCID 866111945-Aminothiazole 2-mercaptoacetic acid ethyl esterHCID 86611218HCID 86611218, compound

Product 1

HCID 57883716HCID 57883716, compound

Procedure

{2-[3-Cyclohexyl-3-(4,4-difluoro-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester prepared using general procedures (A) and (B) using cyclohexyl-(4,4-difluoro-cyclohexyl)-amine and 5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound.

Workup

  1. customHydrolysis

Sources & evidence

ORD record
ord-08cbbc3ddc464965b6d59012f0052346
Source dataset
uspto-grants-2011_01
Patent number
US07872139B2

Reaction notes

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