4-(2-Chloroethyl)morpholine → HCID 86611223, compound

HRID 253920Notes

Reaction equation

HRID 253920 reaction equation
[CH:1]1([N:7]([C@H:19]2[CH2:23][CH2:22][N:21]([C:24](=[O:26])[CH3:25])[CH2:20]2)[C:8]([NH:10][C:11]2[S:12][C:13]([S:16]C#N)=[CH:14][N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.SC[C@@H]([C@@H](CS)O)O.Cl[CH2:36][CH2:37][N:38]1[CH2:43][CH2:42][O:41][CH2:40][CH2:39]1>>[C:24]([N:21]1[CH2:22][CH2:23][C@H:19]([N:7]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[C:8]([NH:10][C:11]2[S:12][C:13]([S:16][CH2:36][CH2:37][N:38]3[CH2:43][CH2:42][O:41][CH2:40][CH2:39]3)=[CH:14][N:15]=2)=[O:9])[CH2:20]1)(=[O:26])[CH3:25]

Participants

4

Reactant 3

HCID 767274-(2-Chloroethyl)morpholineHCID 439352DithioerythritolHCID 86611224HCID 86611224, compound

Product 1

HCID 86611223HCID 86611223, compound

Procedure

Prepared as described in general procedure (H) using 1-cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-1-[1-(acetyl)-pyrrolidin-3(S)-yl]-urea, dithioerythritol and N-(2-chloroethyl)morpholine

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1be54cd3fad14192943bd3c87efcd13d
Source dataset
uspto-grants-2011_01
Patent number
US07872139B2

Reaction notes

Loading…