Acetyl chloride → HCID 22567102, compound

HRID 25403Notes

Reaction equation

HRID 25403 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][S:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[S:21]([CH3:24])(=[O:23])=[O:22])(=[O:14])=[O:13])[CH:9]=2)[NH:4][N:3]=1.[C:25](Cl)(=[O:27])[CH3:26]>N1C=CC=CC=1>[CH3:24][S:21]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[S:12]([NH:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][N:3]=[C:2]2[NH:1][C:25](=[O:27])[CH3:26])(=[O:13])=[O:14])(=[O:23])=[O:22]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 22567244HCID 22567244, compound

Product 1

HCID 22567102HCID 22567102, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

N-[5-(2-Methylsulfonylbenzenesulfonylamino)-1H-indazol-3-yl)-acetamide can be obtained as described in Example 28 from 0.5 g of N-(3-amino-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide, 3 ml of pyridine and 98 μl of acetyl chloride. 338 mg of N-[5-(2-methylsulfonylbenzenesulfonylamino)-1H-indazol-3-yl)-acetamide are thus obtained in the form of a white solid which decomposes at approximately 145° C. (analysis C16H16N4O5S2 % calculated C, 47.05; H, 3.95; N, 13.72; O, 19.59; S, 15.7. % found C, 46.96; H, 4.27; N, 13.23; S, 14.91).

Sources & evidence

ORD record
ord-03fb98e254f2469cb1fb25e7dc30b93e
Source dataset
uspto-grants-2005_02
Patent number
US06858638B2

Reaction notes

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