Acetyl chloride → N-[5-(3,5-difluorobenzenesulfonylamino)-1H-indazol-3-yl)-acetamide

HRID 25404Notes

Reaction equation

HRID 25404 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][S:12]([C:15]3[CH:20]=[C:19]([F:21])[CH:18]=[C:17]([F:22])[CH:16]=3)(=[O:14])=[O:13])[CH:9]=2)[NH:4][N:3]=1.[C:23](Cl)(=[O:25])[CH3:24]>N1C=CC=CC=1>[F:21][C:19]1[CH:20]=[C:15]([S:12]([NH:11][C:8]2[CH:9]=[C:10]3[C:5](=[CH:6][CH:7]=2)[NH:4][N:3]=[C:2]3[NH:1][C:23](=[O:25])[CH3:24])(=[O:14])=[O:13])[CH:16]=[C:17]([F:22])[CH:18]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 22567125N-(3-amino-1H-indazol-5-yl)-3,5-difluorobenzenesulfonamide

Product 1

HCID 22567091N-[5-(3,5-difluorobenzenesulfonylamino)-1H-indazol-3-yl)-acetamide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

N-[5-(3,5-Difluorobenzenesulfonylamino)-1H-indazol-3-yl]acetamide can be obtained as described in Example 28 from 0.1 g of N-(3-amino-1H-indazol-5-yl)-3,5-difluorobenzenesulfonamide, 9 ml of pyridine and 0.024 ml of acetyl chloride. 338 mg of N-[5-(3,5-difluorobenzenesulfonylamino)-1H-indazol-3-yl)acetamide are thus obtained in the form of a cream solid melting at 268° C.

Sources & evidence

ORD record
ord-a1844fc440264288ba6ea296ab580941
Source dataset
uspto-grants-2005_02
Patent number
US06858638B2

Reaction notes

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