Benzoyl chloride → N-[5-(3,5-difluorobenzenesulfonylamino)-1H-indazol-3-yl)benzamide

HRID 25406Notes

Reaction equation

HRID 25406 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][S:12]([C:15]3[CH:20]=[C:19]([F:21])[CH:18]=[C:17]([F:22])[CH:16]=3)(=[O:14])=[O:13])[CH:9]=2)[NH:4][N:3]=1.[C:23](Cl)(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>N1C=CC=CC=1>[F:21][C:19]1[CH:20]=[C:15]([S:12]([NH:11][C:8]2[CH:9]=[C:10]3[C:5](=[CH:6][CH:7]=2)[NH:4][N:3]=[C:2]3[NH:1][C:23](=[O:30])[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)(=[O:14])=[O:13])[CH:16]=[C:17]([F:22])[CH:18]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 22567125N-(3-amino-1H-indazol-5-yl)-3,5-difluorobenzenesulfonamide

Product 1

HCID 22567035N-[5-(3,5-difluorobenzenesulfonylamino)-1H-indazol-3-yl)benzamide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

N-[5-(3,5-Difluorobenzenesulfonylamino)-1H-indazol-3-yl]benzamide can be obtained as described in Example 28 from 0.15 g of N-(3-amino-1H-indazol-5-yl)-3,5-difluorobenzenesulfonamide, 13.5 ml of pyridine and 0.06 ml of benzoyl chloride. 30 mg of N-[5-(3,5-difluorobenzenesulfonylamino)-1H-indazol-3-yl)benzamide are thus obtained in the form of a cream solid melting at 246° C. (analysis C20H14F2N4O3S.1.33H2O % calculated C, 56.08; H, 3.29; F, 8.87; N, 13.08; O, 11.20; S, 7.48. % found C, 56.49; H, 3.38; N, 11.90; S, 6.95).

Sources & evidence

ORD record
ord-d1fed6e5bbfd4965b9fcd45c932f65a5
Source dataset
uspto-grants-2005_02
Patent number
US06858638B2

Reaction notes

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