HCID 178447926, compound → HCID 178448089, compound

HRID 254122Notes

Reaction equation

HRID 254122 reaction equation
[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([CH:10]2[CH2:13][CH2:12][O:11]2)[CH2:6][CH2:5]1)[CH2:2][CH3:3].[CH2:14]([C@H:16]1[CH2:21][CH2:20][C@H:19]([CH2:22][C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:18][CH2:17]1)[CH3:15]>>[CH2:14]([C@H:16]1[CH2:21][CH2:20][C@H:19]([CH:22]([CH2:12][CH2:13][CH:10]([OH:11])[C@H:7]2[CH2:8][CH2:9][C@H:4]([CH2:1][CH2:2][CH3:3])[CH2:5][CH2:6]2)[C:23]([O:25][C:26]([CH3:27])([CH3:29])[CH3:28])=[O:24])[CH2:18][CH2:17]1)[CH3:15]

Participants

3

Reactant 2

HCID 178447926HCID 178447926, compoundHCID 178455749HCID 178455749, compound

Product 1

HCID 178448089HCID 178448089, compoundYield 85.3%

Procedure

Reaction operations were carried out according to the first step of Example 1 by using 1-(trans-4-propylcyclohexyl)oxetane (37) (3.1 g, 17.0 mmol) and tert-butyl 2-(trans-4-ethylcyclohexyl)acetate (40) (12.3 g, 54.4 mmol) as starting materials to obtain tert-butyl 2-(trans-4-ethylcyclohexyl)-5-hydroxy-5-(trans-4-propylcyclohexyl)pentanoate (41) (6.8 g, 14.5 mmol). The yield based on the compound (37) was 85%.

Workup

  1. customReaction operations

Sources & evidence

ORD record
ord-6657ce4b20114af9b10f415b0ae37e2e
Source dataset
uspto-grants-2011_01
Patent number
US07875327B2

Reaction notes

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