Hydrochloric Acid → HCID 11472819, compound

Participants

Reaction Steps

A solution of 2-amino-6-(2-furyl)-N-(6-(triphenylmethoxymethyl)pyridin-2-ylmethyl)pyrimidine-4-carboxamide (3.41 g, 6 mmol) in MeOH (50 mL) was treated with 4-M HCl in dioxane (7.5 mL, 30 mmol), stirred at room temperature for 20 h and concentrated in vacuo. The residue was diluted with water (50 mL) basified with 5-M NaOH, extracted with EtOAc (2×25 mL) and the combined organic phase washed with brine (25 mL), dried (MgSO4) and concentrated in vacuo to give the title compound (1.19 g, 61%) as a cream solid.

Provenance & Evidence